Holmes K K, Berger R E, Alexander E R
Arch Androl. 1979 Dec;3(4):309-16. doi: 10.3109/01485017908988421.
Fifty patients with acute epididymitis were evaluated prospectively by history, examination, and microbiologic studies, including cultures for aerobes, anaerobes, N. gonorrhoeae, Chlamydia trachomatis, and Ureaplasma urealyticum. E. Coli was the predominant pathogen isolated from the urine of men over 35 years old and C. trachomatis and N. gonnorrheae were the predominant pathogens isolated from the urethra of men under 35. The etiologic role of E. Coli and C. trachomatis was confirmed by isolation from epididymal aspirates from a high proportion of men with positive urine of urethral cultures for these agents. C. trachomatis epididymitis accounted for two thirds of "idiopathic epididymitis" in men, and was often associated with oligozoospermia. Of nine female sexual partners of men with C. trachomatis infection, six had antibody to C. trachomatis, of whom two had positive cervical cultures for this organism, and the others had nongonococcal pelvic inflammatory disease. Antibiotic therapy with tetracycline was effective for the treatment of men with C. trachomatis epididymitis, and should be offered to their female sex partner.
对50例急性附睾炎患者进行了前瞻性评估，评估内容包括病史、体格检查和微生物学研究，其中微生物学研究包括需氧菌、厌氧菌、淋病奈瑟菌、沙眼衣原体和解脲脲原体培养。大肠杆菌是35岁以上男性尿液中分离出的主要病原体，沙眼衣原体和淋病奈瑟菌是35岁以下男性尿道中分离出的主要病原体。从大量尿液或尿道培养物呈阳性的男性附睾吸出物中分离出大肠杆菌和沙眼衣原体，证实了它们在病因学上的作用。沙眼衣原体附睾炎占男性“特发性附睾炎”的三分之二，且常与少精子症相关。在9名感染沙眼衣原体男性的女性性伴侣中，6人有沙眼衣原体抗体，其中2人宫颈培养该病原体呈阳性，其他人患有非淋菌性盆腔炎。四环素抗生素治疗对沙眼衣原体附睾炎男性有效，且应给予其女性性伴侣治疗。
