Smith G N, Mickler E A, Albrecht M E, Myers S L, Brandt K D
Rheumatology Division, Department of Medicine, and Department of Anatomy, Indiana University School of Medicine, Indianapolis, IN 46202-5103, USA.
Osteoarthritis Cartilage. 2002 Apr;10(4):321-6. doi: 10.1053/joca.2002.0520.
To examine the relationship between the severity of cartilage damage and the severity of meniscus damage after transection of the anterior cruciate ligament (ACLT) in adult dogs.
Data were obtained from 40 dogs which underwent ACLT and from three additional sham-operated dogs that were subjected to arthrotomy but not ligament transection. Joint pathology was analysed 12, 24 or 32 weeks after surgery. The severity of damage to the articular cartilage on the femoral condyle and tibial plateau was graded with a scoring system based on that of the Sociètè Française d'Arthroscopie and meniscus damage was graded on a 0-4 scale.
No damage to the meniscus or articular cartilage was observed 12 weeks after surgery in the dogs subjected only to arthrotomy. In contrast, tears of the medial meniscus were observed in two of 10 (20%) dogs examined 12 weeks after ACLT. The incidence of severe tears increased to 86% and 84% after 24 weeks and 32 weeks, respectively. Damage to the lateral meniscus was mild, with only 7.5% of all dogs with a cruciate-deficient knee having a bucket handle or complete tear. Most of the unstable knees exhibited ulceration of the articular cartilage of the femoral condyles and tibial plateaus 12 weeks (mean chondropathy score+/-standard deviation 11.9+/-8.5, N=10), 24 weeks (7.9+/-5.0, N=7), and 32 weeks (7.1+/-5.5, N=23) after ACLT. The mean chondropathy scores for the tibial plateaus were similar to those for the femoral condyles. No correlation was apparent between the severity of cartilage damage and of meniscus damage for either joint surface.
Damage to the medial meniscus is a consistent feature of the pathology which develops in the canine knee after ACLT, but the severity of cartilage damage is not correlated with the severity of meniscal damage.
研究成年犬前交叉韧带横断（ACLT）后软骨损伤严重程度与半月板损伤严重程度之间的关系。
数据来自40只接受ACLT的犬以及另外3只接受关节切开术但未进行韧带横断的假手术犬。在术后12、24或32周分析关节病理学情况。基于法国关节镜协会的评分系统对股骨髁和胫骨平台的关节软骨损伤严重程度进行分级，半月板损伤按0 - 4级进行分级。
仅接受关节切开术的犬在术后12周未观察到半月板或关节软骨损伤。相比之下，在接受ACLT后12周检查的10只犬中有2只（20%）观察到内侧半月板撕裂。严重撕裂的发生率在24周和32周后分别增至86%和84%。外侧半月板损伤较轻，在所有患有十字韧带损伤膝关节的犬中，只有7.5%出现桶柄状或完全撕裂。大多数不稳定膝关节在ACLT后12周（平均软骨病评分±标准差11.9±8.5，N = 10）、24周（7.9±5.0，N = 7）和32周（7.1±5.5，N = 23）时出现股骨髁和胫骨平台关节软骨溃疡。胫骨平台的平均软骨病评分与股骨髁相似。对于任一关节面，软骨损伤严重程度与半月板损伤严重程度之间均无明显相关性。
内侧半月板损伤是犬ACLT后膝关节病理变化的一个持续特征，但软骨损伤严重程度与半月板损伤严重程度无关。
