改良前交叉韧带横断模型中半月板力学及蛋白聚糖含量的评估
Evaluation of meniscal mechanics and proteoglycan content in a modified anterior cruciate ligament transection model.
作者信息
Fischenich Kristine M, Coatney Garrett A, Haverkamp John H, Button Keith D, DeCamp Charlie, Haut Roger C, Haut Donahue Tammy L
出版信息
J Biomech Eng. 2014 Jul;136(7):0710011-8. doi: 10.1115/1.4027468.
Abstract
Post-traumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen.
摘要
创伤后骨关节炎（PTOA）是由导致膝关节软组织撕裂的创伤性负荷引起的。在骨骼成熟的弗拉芒巨兔身上使用了一种改良的横断模型，即切断前交叉韧带（ACL）和两个半月板。在损伤后12周，通过对半月板进行大体形态学评估、弹性模量测定和糖胺聚糖（GAG）覆盖面积测定来量化组织损伤量。本研究是最早监测半月板和ACL联合横断术后半月板变化的研究之一。结果发现弹性模量降低以及GAG覆盖面积减少。
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