Zhu Xiuwen, Ganesan A
Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom.
J Org Chem. 2002 Apr 19;67(8):2705-8. doi: 10.1021/jo010996b.
Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Hünig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a S(N)1-like pathway, and is general for allylic, benzylic, and tertiary halides.
发现在Hünig碱和碘化四丁铵存在下，三氟甲磺酸锌是一种用于通过卤代烃对吲哚进行C3-烷基化的有效试剂。这种吲哚烷基化的新方法通过类似S(N)1的途径进行，并且对烯丙基、苄基和叔卤代烃具有通用性。
