Yang Yaqi, Ye Zihang, Zhang Xu, Zhou Yipeng, Ma Xiantao, Cao Hongen, Li Huan, Yu Lei, Xu Qing
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, P. R. China.
Org Biomol Chem. 2017 Nov 22;15(45):9638-9642. doi: 10.1039/c7ob02461d.
Alcohols can be efficiently converted into the useful thioethers by a transition metal- and base-free dehydrative S-alkylation reaction with thiols or disulfides by employing alkyl halides as the effective catalyst. This simple and efficient method is a green and practical way for the preparation of thioethers, as it tolerates a wide range of substrates such as aryl and alkyl thiols, as well as benzylic, allylic, secondary, tertiary, and even the less reactive aliphatic alcohols.
通过使用卤代烃作为有效催化剂，醇类可通过与硫醇或二硫化物进行无过渡金属和碱的脱水S-烷基化反应，高效转化为有用的硫醚。这种简单高效的方法是制备硫醚的绿色实用途径，因为它能耐受多种底物，如芳基硫醇和烷基硫醇，以及苄基、烯丙基、仲醇、叔醇，甚至是反应活性较低的脂肪醇。
