耻骨宫颈筋膜胶原蛋白含量减少是女性真性压力性尿失禁手术治疗失败的危险因素吗？

Is diminished pubocervical fascia collagen content a risk factor for failure of surgical management of genuine stress urinary incontinence in women?

作者信息

Skorupski Pawel, Rechberger Tomasz, Postawski Krzysztof, Woessner J Frederick, Jakowicki Jerzy A

机构信息

Department of Gynecological Surgery, University School of Medicine, 20-954 Lublin, Jaczewskiego 8, Poland

出版信息

Eur J Obstet Gynecol Reprod Biol. 2002 May 10;102(2):195-8. doi: 10.1016/s0301-2115(01)00587-5.

DOI:10.1016/s0301-2115(01)00587-5

PMID:11950490

Abstract

OBJECTIVE

The assessment of relationship between pubocervical collagen content and clinical results of surgical treatment of genuine stress urinary incontinence (GSUI) in women.

METHODS

Twenty-four women treated for genuine stress urinary incontinence were included into the study. All women underwent the same surgical procedure. The samples of pubocervical fascia were taken at the time of surgery. The contents of acid soluble, pepsin soluble, insoluble fraction of collagen, total collagen and collagen crosslinks were measured. The study of pubocervical fascia collagen metabolism included also estimation of collagenase activity. At follow-up done 5 years following surgery, 20 patients reported symptoms of GSUI (study group). Four women were still without symptoms of urine leakage (control group).

RESULTS

The biochemical parameters of pubocervical fascia did not show, statistically significant differences between compared groups.

CONCLUSION

The pubocervical fascia collagen metabolism does not have impact on the results of anti-incontinence surgery.

摘要

目的

评估耻骨宫颈胶原含量与女性真性压力性尿失禁（GSUI）手术治疗临床结果之间的关系。

方法

24例接受真性压力性尿失禁治疗的女性纳入本研究。所有女性均接受相同的手术操作。在手术时采集耻骨宫颈筋膜样本。测量胶原的酸溶性、胃蛋白酶溶性、不溶性部分、总胶原和胶原交联物的含量。耻骨宫颈筋膜胶原代谢的研究还包括胶原酶活性的评估。术后5年进行随访时，20例患者报告有GSUI症状（研究组）。4名女性仍无尿漏症状（对照组）。