Tunn R, Rieprich M, Kaufmann O, Gauruder-Burmester A, Beyersdorff D
Department of Obstetrics and Gynecology, Charité University Hospital, Humboldt University, Berlin, Germany.
Int Urogynecol J Pelvic Floor Dysfunct. 2005 Nov-Dec;16(6):480-6. doi: 10.1007/s00192-005-1302-9. Epub 2005 Jul 21.
To correlate MRI with histologic findings of the suburethral pubocervical fascia in women with urodynamic stress incontinence. Thirty-one women with urodynamically proven stress urinary incontinence without relevant prolapse underwent preoperative MRI. Tissue specimens obtained from the pubocervical fascia were examined immunohistochemically (types I and III collagen, smooth muscle actin) and the results compared with the MRI findings. MRI demonstrated an intact pubocervical fascia in 61.3% of the cases and a fascial defect in 38.7%. A fascial defect demonstrated by MRI was associated with a decrease in actin (P<0.09) and an increase in collagen III (P<0.01) compared to an intact fascia. In women with stress urinary incontinence, smooth muscle actin in the pubocervical fascia is decreased, changed in structure, and replaced by type III collagen. MRI allows evaluation of the pubocervical fascia and its morphologic changes.
将尿动力学压力性尿失禁女性患者的MRI表现与尿道下耻骨宫颈筋膜的组织学结果进行相关性研究。31例经尿动力学证实为压力性尿失禁且无相关脏器脱垂的女性患者接受了术前MRI检查。从耻骨宫颈筋膜获取的组织标本进行免疫组织化学检查（I型和III型胶原、平滑肌肌动蛋白），并将结果与MRI表现进行比较。MRI显示61.3%的病例耻骨宫颈筋膜完整，38.7%存在筋膜缺损。与完整筋膜相比，MRI显示的筋膜缺损与肌动蛋白减少（P<0.09）和III型胶原增加（P<0.01）相关。在压力性尿失禁女性中，耻骨宫颈筋膜中的平滑肌肌动蛋白减少、结构改变并被III型胶原取代。MRI可评估耻骨宫颈筋膜及其形态学变化。
