Jaffer Zahara M, Chernoff Jonathan
Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.
Int J Biochem Cell Biol. 2002 Jul;34(7):713-7. doi: 10.1016/s1357-2725(01)00158-3.
The p21-activated kinases (Paks) are serine/threonine protein kinases that bind to and, in some cases, are stimulated by activated forms of the small GTPases, Cdc42 and Rac. With the recent discovery of several novel isoforms, Paks are now categorized into two subgroups based on architectural similarities. The Group I Paks (Pak1, Pak2, Pak3) have been studied in greater detail and shown to be involved in the regulation of cellular processes such as gene transcription, cell morphology, motility, and apoptosis. Here we summarize recent findings that shed light on the newly recognized Group II Paks (Pak4, Pak5, Pak6) and review both similarities and differences between kinases of the two Pak subgroups.
p21激活激酶（Paks）是丝氨酸/苏氨酸蛋白激酶，可与小GTP酶Cdc42和Rac的活化形式结合，在某些情况下还会被其激活。随着最近几种新亚型的发现，根据结构相似性，Paks现在被分为两个亚组。I组Paks（Pak1、Pak2、Pak3）已得到更深入的研究，并显示参与细胞过程的调节，如基因转录、细胞形态、运动和凋亡。在此，我们总结了最近有关新发现的II组Paks（Pak4、Pak5、Pak6）的研究结果，并综述了两个Pak亚组激酶之间的异同。
