Starling J A, Fisher F M
J Parasitol. 1975 Dec;61(6):977-90.
The uptakes of 14C-glucose, -2-deoxyglucose, -mannose, -N-acetylglucosamine, -3-0-methylglucose, -fructose, and -galactose by female Moniliformis dubius were nonlinear, saturable functions of hexose concentration. Kinetic and inhibition studies indicated that glucose and 2-deoxyglucose were absorbed via a single common transport locus. Mannose, N-acetylglucosamine, 3-0-methylglucose, fructose, and galactose (in decreasing order of effectiveness) inhibited the uptake of glucose in a completely competitive manner; their absorptions appeared to be mediated by the glucose transport locus and, to some degree, by one or more additional transport systems. Kinetic studies suggested that the apparent inhibitions of 14C-glucose uptake by maltose and glucose-6-phosphate were due to free glucose liberated through the action of surface hydrolases. The uptake of 14C-glucose was also inhibited by salicin, alpha-methylglucoside, and beta-methylglucoside, but not by pentoses, L-hexoses, sugar alcohols, disaccharides (except maltose), gluconic acid, glucuronic acid, phlorizin, or ouabain. Glucose uptake was not Na+-dependent.
雌性念珠棘虫对14C-葡萄糖、-2-脱氧葡萄糖、-甘露糖、-N-乙酰葡糖胺、-3-O-甲基葡萄糖、-果糖和-半乳糖的摄取是己糖浓度的非线性、可饱和函数。动力学和抑制研究表明，葡萄糖和2-脱氧葡萄糖通过单一共同转运位点被吸收。甘露糖、N-乙酰葡糖胺、3-O-甲基葡萄糖、果糖和半乳糖（按有效性递减顺序）以完全竞争性方式抑制葡萄糖的摄取；它们的吸收似乎由葡萄糖转运位点介导，并在一定程度上由一个或多个额外的转运系统介导。动力学研究表明，麦芽糖和葡萄糖-6-磷酸对14C-葡萄糖摄取的明显抑制是由于表面水解酶作用释放的游离葡萄糖所致。14C-葡萄糖的摄取也受到水杨苷、α-甲基葡糖苷和β-甲基葡糖苷的抑制，但不受戊糖、L-己糖、糖醇、二糖（麦芽糖除外）、葡萄糖酸、葡萄糖醛酸、根皮苷或哇巴因的抑制。葡萄糖摄取不依赖于Na+。
