Horner R, Elidan J, Sadovsky E, Diamant Y Z, Polishuk W Z
J Perinat Med. 1975;3(1):68-72. doi: 10.1515/jpme.1975.3.1.68.
Leukocyte alkaline phosphatase (LAP) activity increases progressively during pregnancy, returning to non-pregnant levels 6 weeks post-partum. This enzymatic activity is under the influence of placental steroid hormones, thus reflecting placental function. LAP activity is thus a reflection of the dynamic relations between estrogenic, progestational and corticoid activity during pregnancy. LAP activity was studied in 60 women and in their 61 newborn infants at delivery and during the first five days of the puerperium. The Kaplow cytochemical technique was employed. The average maternal LAP score as well as the average newborn infant LAP score was considerably higher than the LAP score of the normal adult. The level of the enzyme in the maternal granulocytes was significantly higher than that of the newborn (Tab. I). During the first five days after labor, there was progressive decrease in the LAP score in the maternal and the newborn blood; on the fifth day the LAP scores of both were only slightly above the normal adult score (Figs. 1, 2). An inverse relation between the LAP score and the birth weight of the infant was found (Tab. III). These results confirm the view that LAP activity in the fetus in utero, are dependent on placental steroid function. The lower LAP values in the newborn, as compared to those of the mother are probably dependent on the lower newborn hormone levels. The significance of the relation between LAP scores and the infants birth weight is not clear.
白细胞碱性磷酸酶（LAP）活性在孕期逐渐升高，产后6周恢复到非孕期水平。这种酶活性受胎盘甾体激素影响，从而反映胎盘功能。因此，LAP活性反映了孕期雌激素、孕激素和皮质激素活性之间的动态关系。对60名妇女及其61名新生儿在分娩时及产褥期的头五天进行了LAP活性研究。采用了卡普洛细胞化学技术。产妇LAP平均评分以及新生儿LAP平均评分均显著高于正常成年人的LAP评分。产妇粒细胞中的酶水平显著高于新生儿（表I）。分娩后的头五天，产妇和新生儿血液中的LAP评分逐渐下降；在第五天，两者的LAP评分仅略高于正常成年人评分（图1、2）。发现LAP评分与婴儿出生体重呈负相关（表III）。这些结果证实了子宫内胎儿的LAP活性依赖于胎盘甾体功能这一观点。与母亲相比，新生儿的LAP值较低可能取决于新生儿较低的激素水平。LAP评分与婴儿出生体重之间关系的意义尚不清楚。
