Wu Zhong, Shi Yingkang
Department of Thoracic and Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu 610041.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2002 Jan;19(1):132-4.
Valve replacement represents the most common surgical therapy for valvular heart diseases. However, the long-term results of the valve protheses in clinical use are not satisfying. Recently, with the development of tissue engineering, more and more studies are focusing on creating ideal valve substitutes through seeding autologous cells on biodegradable scaffold. This article describes the definition of valvular tissue engineering, the choice of scaffold biomaterials, the methods of cell culture and seeding, and the evaluation of tissue-engineered heart valves. Furthermore, the problems which should be resolved in the future are also presented in the article.
瓣膜置换是治疗心脏瓣膜疾病最常见的外科手术方法。然而，临床使用的瓣膜假体的长期效果并不理想。近年来，随着组织工程学的发展，越来越多的研究致力于通过将自体细胞接种在可生物降解支架上来构建理想的瓣膜替代物。本文阐述了瓣膜组织工程的定义、支架生物材料的选择、细胞培养和接种方法以及组织工程心脏瓣膜的评估。此外，本文还提出了未来需要解决的问题。
