Mol Anita, Bouten Carlijn V C, Baaijens Frank P T, Zünd Gregor, Turina Marko I, Hoerstrup Simon P
University Hospital Zurich, Clinic for Cardiovascular Surgery, Zurich, Switzerland.
J Heart Valve Dis. 2004 Mar;13(2):272-80.
Heart valve replacement represents the most common surgical therapy for end-stage valvular heart diseases. One major drawback that all heart valve replacements have in common is the lack of growth, repair, and remodeling capability once implanted into the body. The emerging field of tissue engineering is focusing on the in-vitro generation of functional, living semilunar heart valve replacements. This review presents a state-of-the-art overview of the physiological and biomechanical requirements of semilunar heart valves, focusing on the aortic valve. Moreover, recent heart valve tissue engineering is summarized and future options and improvements on the way towards clinical applications are discussed.
心脏瓣膜置换是终末期瓣膜性心脏病最常见的外科治疗方法。所有心脏瓣膜置换术的一个主要共同缺点是一旦植入体内就缺乏生长、修复和重塑能力。新兴的组织工程领域专注于体外生成功能性、有生命的半月形心脏瓣膜替代品。本文综述了半月形心脏瓣膜的生理和生物力学要求的最新概况，重点是主动脉瓣。此外，总结了近期心脏瓣膜组织工程，并讨论了在临床应用道路上的未来选择和改进。
