Maes B, De Wolf-Peeters C
Department of Morphology and Molecular Pathology, Katholieke Universiteit Leuven, Leuven, Belgium.
Histopathology. 2002 Feb;40(2):117-26. doi: 10.1046/j.1365-2559.2002.01360.x.
The marginal zone represents one of the distinct compartments of the B-cell area in lymphoid tissues. It is especially well developed in the spleen and in Peyer's patches of the gut, but not in lymph nodes, with the exception of the ones in the mesenterium. However, the pronounced proliferation of so-called 'monocytoid B-cells' that may be seen in some inflammatory conditions of the lymph node may be regarded as a nodal reactive marginal zone cell expansion. The cellular compositions of the marginal zone and the monocytoid B-cell proliferation are similar and both show a heterogeneous population of B-cells, of which the functions are being slowly unravelled. Neoplasms originating in the marginal zone have been recognized in the past and are listed in the REAL classification as marginal zone B-cell lymphomas including extranodal MALT-type lymphomas, splenic marginal zone lymphomas and nodal (monocytoid) marginal zone lymphomas. Marginal zone cell lymphomas display a broad morphological spectrum, which is reflected by the heterogeneity of the cellular composition and the variation in the growth pattern of the lymphoma, but is independent of the anatomical site. All three marginal zone cell lymphomas share immunophenotypic, genetic and chromosomal similarities which will be discussed. The morphologic features are dealt with only briefly as they have been extensively discussed elsewhere.
边缘区是淋巴组织中B细胞区的不同组成部分之一。它在脾脏和肠道的派尔集合淋巴结中发育良好，但在淋巴结中除肠系膜淋巴结外发育不佳。然而，在淋巴结的某些炎症状态下可见的所谓“单核细胞样B细胞”的显著增殖可被视为淋巴结反应性边缘区细胞扩增。边缘区和单核细胞样B细胞增殖的细胞组成相似，且均显示出异质性的B细胞群体，其功能正逐渐被揭示。过去已认识到起源于边缘区的肿瘤，在REAL分类中被列为边缘区B细胞淋巴瘤，包括结外黏膜相关淋巴组织型淋巴瘤、脾边缘区淋巴瘤和淋巴结（单核细胞样）边缘区淋巴瘤。边缘区细胞淋巴瘤表现出广泛的形态学谱，这反映在细胞组成的异质性和淋巴瘤生长模式的变化上，但与解剖部位无关。所有这三种边缘区细胞淋巴瘤都具有免疫表型、基因和染色体相似性，将对此进行讨论。形态学特征仅作简要处理，因为它们已在其他地方进行了广泛讨论。
