Jung Tae-Young, Jung Shin, Lee Min-Cheol, Lee Kyung-Hwa
Department of Neurosurgery, Chonnam National University Hwasun Hospital, 160, Ilsim-ri, Hwasun-eup, Hwasun-gun, Jeollanam-do, 519-809, Republic of Korea.
J Neurooncol. 2006 Oct;80(1):63-7. doi: 10.1007/s11060-006-9153-x. Epub 2006 Apr 21.
We report a case of extranodal marginal zone B-cell lymphoma (MZL) mimicking meningioma in a lateral ventricle and suggest its possible pathogenesis. The patient was a 63-year-old male with seizure attack. MRI showed a 3.5x1.7 cm sized homogeneously enhancing mass in the trigon of the right lateral ventricle, possibly arising from the choroid plexus. The provisional diagnosis was meningioma or metastasis. In the surgical findings, the mass was attached to the choroid plexus and totally removed. Pathologic examination revealed a monotonous population of medium-sized mononuclear lymphoma cells associated with meningothelial whorl formation and neoplastic cells which invaded the meningothelial cells. The tumor was immunopositive for CD79a, CD20, CD43 and bcl-2. We suggest that intracranial extranodal marginal zone B-cell lymphomas might mimic meningiomas, because of their relation with the arachnoid cells and that meningothelial cells serve as a substitute for the mucosal surface in intracranial MALT lymphomas.
我们报告一例发生于侧脑室、酷似脑膜瘤的结外边缘区B细胞淋巴瘤（MZL）病例，并提出其可能的发病机制。患者为一名63岁有癫痫发作的男性。MRI显示右侧脑室三角区有一个大小为3.5×1.7 cm的均匀强化肿块，可能起源于脉络丛。初步诊断为脑膜瘤或转移瘤。手术所见肿块附着于脉络丛并被完整切除。病理检查显示为中等大小单核淋巴瘤细胞的单一性群体，伴有脑膜上皮漩涡形成以及侵袭脑膜上皮细胞的肿瘤细胞。肿瘤对CD79a、CD20、CD43和bcl-2免疫阳性。我们认为颅内结外边缘区B细胞淋巴瘤可能酷似脑膜瘤，因为它们与蛛网膜细胞有关，并且脑膜上皮细胞在颅内黏膜相关淋巴组织淋巴瘤中可替代黏膜表面。
