Fang A W, Whittaker M A, Theaker J M
Department of Histopathology, Southampton General Hospital, Southampton, UK.
Histopathology. 2002 Feb;40(2):177-9. doi: 10.1046/j.1365-2559.2002.01323.x.
To determine the incidence of mucinous metaplasia occurring in the foreskin or glans penis and any associated clinical or histopathological features.
Following the recognition of two index cases, 100 other foreskin specimens were retrieved from the histopathology archives at Southampton General Hospital. The haematoxylin and eosin-stained slides were examined by a single observer to detect the presence of mucin-producing cells in the surface epithelium. The absence of mucinous metaplasia in negative cases was confirmed with mucin histochemistry. In total, four cases of mucinous metaplasia were identified, three involving the foreskin and one involving the glans penis. The age range was 51-80 years. Three cases were associated with Zoon's balanitis and the fourth showed mild non-specific balanitis. All four cases showed positive staining with both diastase periodic acid-Schiff and alcian blue. No mucin-producing cells were identified in non-inflamed or minimally inflamed specimens.
Mucinous metaplasia of the penis is an uncommon but under-recognized condition. It is seen in the elderly and appears to be a metaplastic change associated with severe chronic inflammation, and possibly more specifically with Zoon's balanitis. Our study identified a case affecting the glans penis, a site not previously recorded.
确定发生于包皮或阴茎头的黏液化生的发生率以及任何相关的临床或组织病理学特征。
在识别出两例索引病例后，从南安普敦总医院的组织病理学档案中检索了另外100份包皮标本。由一名观察者检查苏木精-伊红染色切片，以检测表面上皮中产生黏液的细胞的存在。阴性病例中黏液化生的缺失通过黏液组织化学得以证实。总共识别出4例黏液化生病例，3例累及包皮，1例累及阴茎头。年龄范围为51至80岁。3例与浆细胞性龟头炎相关，第4例表现为轻度非特异性龟头炎。所有4例对淀粉酶消化过碘酸希夫染色和阿尔辛蓝染色均呈阳性。在未发炎或轻度发炎的标本中未识别出产生黏液的细胞。
阴茎黏液化生是一种罕见但未得到充分认识的病症。它见于老年人，似乎是一种与严重慢性炎症相关的化生改变，可能更具体地与浆细胞性龟头炎相关。我们的研究发现了一例累及阴茎头的病例，这是一个此前未记录的部位。
