Koven I H, MacMillan N, Zhuk A
J Trauma. 1975 Nov;15(11):992-8. doi: 10.1097/00005373-197511000-00009.
We have demonstrated a defect in tissue perfusion during hemorrhagic shock in dogs that is due in part to poor capillary flow, and in part to a defect in interstitial tissue diffusion. Treatment with whole blood alone improves capillary flow but diffusion remains defective. The use of hyaluronidase appears to correct the interstitial diffusion defect observed during shock.
我们已经证实，犬失血性休克期间存在组织灌注缺陷，部分原因是毛细血管血流不佳，部分原因是间质组织扩散存在缺陷。单纯输注全血可改善毛细血管血流，但扩散仍存在缺陷。使用透明质酸酶似乎可以纠正休克期间观察到的间质扩散缺陷。
