Altiparmak M R, Tanverdi M, Pamuk O N, Tunç R, Hamuryudan V
Cerrahpaşa Medical School, University of Istanbul, Turkey.
Clin Rheumatol. 2002 Feb;21(1):14-8. doi: 10.1007/s100670200004.
Despite being recognised much more frequently than in the past, renal involvement has not previously been regarded as a feature of Behcet's disease (BD). In this study we aimed to assess the frequency of renal involvement in BD by performing urinalyses of 674 consecutive BD patients; we also retrospectively evaluated the charts of 4212 BD patients for the incidence of glomerulonephritis (GN). Urinary abnormalities (proteinuria and/or haematuria) were present in 10.8%; and during a period of 23 years GN was detected by renal biopsy in seven (0.16%) BD patients. Two patients with GN were lost to follow-up; end-stage renal failure developed in only one patient, and she underwent renal transplantation. We were unable to determine any pathognomonic feature that was predictive of renal involvement. Although males tend to have a more serious clinical course of BD the incidences of urinary abnormalities and GN were similar in both sexes in our series. According to our results, we can conclude that urinary abnormalities are more frequent in BD; however, serious renal lesions develop in only very few of these patients.
尽管与过去相比，肾脏受累的情况被认识得更为频繁，但此前它并未被视为白塞病（BD）的一个特征。在本研究中，我们旨在通过对674例连续性BD患者进行尿液分析来评估BD患者肾脏受累的频率；我们还回顾性评估了4212例BD患者的病历以了解肾小球肾炎（GN）的发病率。尿液异常（蛋白尿和/或血尿）的发生率为10.8%；在23年的时间里，通过肾活检在7例（0.16%）BD患者中检测到GN。2例GN患者失访；仅1例患者发展为终末期肾衰竭，她接受了肾移植。我们无法确定任何可预测肾脏受累的特征性表现。尽管男性BD患者的临床病程往往更为严重，但在我们的系列研究中，尿液异常和GN的发生率在两性中相似。根据我们的结果，我们可以得出结论，BD患者中尿液异常更为常见；然而，这些患者中只有极少数会发展为严重的肾脏病变。
