Rheumatol Int. 2012 Jul;32(7):2227-9. doi: 10.1007/s00296-011-2051-3. Epub 2011 Jul 23.
Although Behçet's disease (BD) is a kind of systemic disease, renal involvement is rare, especially IgA nephropathy (IgAN). Renal manifestations in BD range from mild urinary abnormalities to glomerulonephritis with persistent renal failure, which includes minimal change disease, proliferative glomerulonephritis, rapidly crescentic glomerulonephritis, renal amyloidosis and IgA nephropathy. Amyloidosis seems to be the most common type of renal lesion in BD, and several cases of nephrotic syndrome secondary to amyloidosis have been documented. Co-occurrence of BD and IgA nephropathy has only been reported in only few cases. We describe two patients with the rare association of BD and IgAN. We suggested that it is important to periodically perform renal function assessment in patients with BD, through urinalysis and measurement of serum creatinine for detecting any abnormality and providing an early adequate treatment.
虽然贝赫切特病（BD）是一种全身性疾病，但肾脏受累很少见，尤其是 IgA 肾病（IgAN）。BD 的肾脏表现从轻度尿异常到伴有持续性肾衰竭的肾小球肾炎不等，包括微小病变病、增生性肾小球肾炎、快速进行性肾小球肾炎、肾淀粉样变性和 IgA 肾病。淀粉样变性似乎是 BD 中最常见的肾脏病变类型，已有数例继发于淀粉样变性的肾病综合征的报道。BD 和 IgA 肾病同时发生的情况仅在少数病例中报道过。我们描述了两例 BD 和 IgAN 罕见合并的患者。我们建议，定期对 BD 患者进行肾功能评估非常重要，通过尿分析和血清肌酐测量来检测任何异常情况，并提供早期充分的治疗。
