青蒿素是否终结了对V(D)J重组中发卡打开活性的探索？
Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?
作者信息
Schlissel Mark S
机构信息
Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
出版信息
Cell. 2002 Apr 5;109(1):1-4. doi: 10.1016/s0092-8674(02)00694-3.
Abstract
When complexed with the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)), the recently discovered dsDNA break repair protein named Artemis acquires the ability to open hairpin DNA molecules in vitro. Both genetic and biochemical data point toward a physiological role for this complex as the elusive hairpin-opening activity in V(D)J recombination.
摘要
当与DNA依赖性蛋白激酶的催化亚基（DNA-PK(cs)）复合时，最近发现的名为Artemis的双链DNA断裂修复蛋白在体外获得了打开发夹状DNA分子的能力。遗传和生化数据均表明，这一复合物在V(D)J重组中具有难以捉摸的发夹打开活性，发挥着生理作用。
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