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[高钠饮食大鼠体内皮质类固醇、儿茶酚胺与电解质之间的关系]

[Relationship between corticosteroids, catecholamines and electrolytes in rats kept on sodium-rich diet].

作者信息

Shorin I P, Papafilova O V, Kim I O, Poliakov L M

出版信息

Kardiologiia. 1975 Aug;15(8):43-7.

PMID:1195548
Abstract

The changes in the content of catecholamines, electrolytes and corticosteroids were studied dynamically and simultaneously in rats under salt stimulation. Long-term maintenance of the animals on sodium-rich diets results in its accumulation in blood plasma and heart muscle, the tissue depot of catecholamines diminishing at the same time. The changes in the functional state of the adrenal glands and of the catecholamines content in the myocardium are of a phased nature. The activation of the glucocorticoid function of the adrenal glands on the 18th day of the experiment is substituted by its reduction on the 56th day. The presence of a distinct relationship between the functional state of the adrenal glands and the level af adrenalin in the heart indicates the regulatory role of glucocorticoids in this experimental situation.

摘要

在盐刺激下,对大鼠体内儿茶酚胺、电解质和皮质类固醇含量的变化进行了动态同步研究。长期给动物喂食富含钠的饮食会导致钠在血浆和心肌中蓄积,同时儿茶酚胺的组织储存量减少。肾上腺功能状态和心肌中儿茶酚胺含量的变化具有阶段性。实验第18天肾上腺糖皮质激素功能的激活在第56天被其功能降低所取代。肾上腺功能状态与心脏中肾上腺素水平之间存在明显的关系,这表明在这种实验情况下糖皮质激素具有调节作用。

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