Chevrier A, Delpech B, Girard N, Nouel J P
Biomedicine. 1979 Oct;30(4):219-23.
Using an antiserum directed against human neurospecific antigen and the indirect immunofluorescence technique, we have obtained evidence for the presence of a mesenchyme associated cross-reacting antigen (MAA) in the dimethylbenzanthracene induced fibrosarcoma of the rat. This antigen has been purified from this tumor and compared with the antigen associated with the human nervous system and that associated with the nervous system of the rat. An anti-rat MAA antiserum has been obtained. It has cytotoxic activity against cultured fibrosarcoma cells as measured by release of radioactivity. This antigen can be considered as a marker of fibrosarcomas.
利用针对人类神经特异性抗原的抗血清和间接免疫荧光技术，我们已获得证据，证实在二甲基苯并蒽诱发的大鼠纤维肉瘤中存在一种间充质相关交叉反应抗原（MAA）。该抗原已从这种肿瘤中纯化出来，并与人类神经系统相关抗原以及大鼠神经系统相关抗原进行了比较。已获得抗大鼠MAA抗血清。通过放射性释放测定，它对培养的纤维肉瘤细胞具有细胞毒性活性。这种抗原可被视为纤维肉瘤的标志物。
