Patetsios Peter, Gable Dennis R, Garrett Wilson V, Lamont Jeffrey P, Kuhn Joseph A, Shutze William P, Kourlis Harry, Grimsley Bradley, Pearl Gregory J, Smith Bertram L, Talkington C M, Thompson Jesse E
Department of Surgery, Division of Vascular Surgery, Baylor University Medical Center, Dallas, TX, USA.
Ann Vasc Surg. 2002 May;16(3):331-8. doi: 10.1007/s10016-001-0106-8. Epub 2002 Apr 18.
Carotid body tumors are rare neoplasms and must be considered in the evaluation of all lateral neck masses; early surgical removal has been recommended. In this study, the medical records of 29 patients with 34 carotid body paragangliomas who were treated at our institution between 1971 and 2001 were retrospectively reviewed. An overview is provided of this lesion, including diagnosis, classification, metastatic potential, possible secretory function, operative techniques, and nonsurgical methods of management. Carotid body tumors may be familial and are more often bilateral in these instances; five patients (17%) had bilateral tumors in this series. The criterion for malignancy is demonstrated by metastatic tumor in lymph nodes or distant organs. Three patients (10%) had malignant tumors, one with hepatic metastases. One patient (3%) in our series exhibited abnormal serotonin production. Vascular reconstruction was necessary in eight cases (28%). No stroke occurred, however, two arterial thromboses (7%), five permanent cranial nerve deficits (17%), and one death (3%) from massive pulmonary embolism were seen. Our experience demonstrates that early operative management is warranted to avoid the possibility of eventual metastasis and progressive local invasion to the point of inoperability.
颈动脉体瘤是一种罕见的肿瘤，在评估所有颈部外侧肿块时均应考虑到；建议早期手术切除。在本研究中，我们回顾性分析了1971年至2001年间在我院接受治疗的29例患有34个颈动脉体副神经节瘤患者的病历。本文对该病变进行了概述，包括诊断、分类、转移潜能、可能的分泌功能、手术技术以及非手术治疗方法。颈动脉体瘤可能具有家族性，在这些情况下更常为双侧性；本系列中有5例患者（17%）患有双侧肿瘤。恶性肿瘤的标准是在淋巴结或远处器官出现转移瘤。3例患者（10%）患有恶性肿瘤，其中1例有肝转移。本系列中有1例患者（3%）血清素分泌异常。8例患者（28%）需要进行血管重建。未发生中风，但出现了2例动脉血栓形成（7%）、5例永久性颅神经功能缺损（17%）以及1例因大面积肺栓塞死亡（3%）。我们的经验表明，早期手术治疗是必要的，以避免最终发生转移以及局部进行性侵袭至无法手术切除的可能性。
