Ndiaye M, Hane A A, Dieng M T, Ndir M, Ba O, Cissokho S, Kandji M, Diatta A, Niang A, Ndiaye B
Service de Pneumophtisiologie C.H.U. de FANN BP: 5035 Dakar/Fann.
Dakar Med. 1999;44(2):236-9.
This study concerns a case-report about a 28 year old Senegalese woman suffering from a SHARP syndrome complicated by a bilateral bacillary pulmonary tuberculosis. The prevalence of this disease is underestimated but a female predominance is often reported. The mechanisms of this disease strongly depends upon the context in with it occurs. The diagnostic has been established by the ALARCON SEGOVIA criteria including clinical symptoms (Raynaud phenomenon, puffy fingers and myalgia) and biological features such as high positive immunofluorescent reactivity revealing the presence of anti RNP antibody at a level superior to 1/1000. The subsequent development figure of the disease emphasizes: persistence of polymyositis pattern revealed by higher limbs localized myalgia involving the thighs and symptoms of lupus including alopecia and glomerulonephritis remaining of the mixed characteristic comparable to the cases published in the literature. appearance of a bilateral bacillary pulmonary tuberculosis with a severe involvement of the right lung. The treatment composed by anti inflammatory and antituberculosis drugs lead to an early improvement of the clinical symptoms associated to a rapid cleaning of radiological manifestations. Sequelae were represented by cavities detected in the right lung and related to the pharmacological effects of corticosteroid drugs.
本研究涉及一例关于一名28岁塞内加尔女性的病例报告，该女性患有夏普综合征，并伴有双侧细菌性肺结核。这种疾病的患病率被低估，但通常报告女性患病率更高。该疾病的发病机制很大程度上取决于其发生的背景。诊断依据阿拉孔·塞戈维亚标准确定，包括临床症状（雷诺现象、手指肿胀和肌痛）以及生物学特征，如高阳性免疫荧光反应，显示抗核糖核蛋白抗体水平高于1/1000。该疾病随后的发展情况表明：持续性多肌炎模式表现为累及大腿的上肢局部肌痛，以及狼疮症状，包括脱发和肾小球肾炎，仍具有与文献中发表的病例相当的混合特征。出现双侧细菌性肺结核，右肺严重受累。由抗炎药和抗结核药组成的治疗方案使临床症状早期改善，同时放射学表现迅速消除。后遗症表现为右肺出现空洞，这与皮质类固醇药物的药理作用有关。
