Prystowsky S D
West J Med. 1980 Apr;132(4):288-93.
A study was done that involved 46 patients with high-titer serum antibody to ribonucleoprotein (RNP). Common cutaneous manifestations included swollen hands or sclerodactyly (50 percent), cutaneous lupus erythematosus (48 percent), periungual telangiectasia (46 percent), alopecia (46 percent), dyspigmentation (28 percent), photosensitivity (28 percent) and vasculitis (22 percent). Frequent systemic characteristics included Raynaud phenomenon (93 percent), arthritis or arthralgia (91 percent), adenopathy (43 percent), vascular headaches (35 percent), serositis (35 percent), hoarseness (28 percent), myositis (26 percent), sicca syndrome (24 percent), renal disease (17 percent) and central nervous system disease (9 percent). Associated laboratory findings included antinuclear antibodies (100 percent), epidermal nuclear lgG deposition (91 percent), hypergammaglobulinemia (78 percent), esophageal dysmotility (61 percent), abnormal pulmonary function (59 percent), rheumatoid factor (57 percent), lupus erythematosus cells (37 percent), positive lupus band test (34 percent), hypocomplementemia (28 percent) and elevated anti-nDNA (21 percent). It appears that patients with high-titer anti-RNP (without appreciable amounts of "anti-Sm") have a high prevalence of Raynaud phenomenon and a low prevalence of progressive renal insufficiency and severe central nervous system disease.
一项研究纳入了46例核糖核蛋白（RNP）血清抗体滴度高的患者。常见的皮肤表现包括手部肿胀或指（趾）硬皮病（50%）、皮肤型红斑狼疮（48%）、甲周毛细血管扩张（46%）、脱发（46%）、色素沉着异常（28%）、光敏性（28%）和血管炎（22%）。常见的全身特征包括雷诺现象（93%）、关节炎或关节痛（91%）、淋巴结病（43%）、血管性头痛（35%）、浆膜炎（35%）、声音嘶哑（28%）、肌炎（26%）干燥综合征（24%）、肾脏疾病（17%）和中枢神经系统疾病（9%）。相关的实验室检查结果包括抗核抗体（100%）、表皮核IgG沉积（91%）、高球蛋白血症（78%）、食管运动障碍（61%）、肺功能异常（59%）、类风湿因子（57%）、红斑狼疮细胞（37%）、狼疮带试验阳性（34%）、补体低下（28%）和抗双链DNA升高（21%）。看来，抗RNP抗体滴度高（无明显量的“抗Sm”）的患者雷诺现象患病率高，进行性肾功能不全和严重中枢神经系统疾病的患病率低。
