Ortiz Cabria Roberto, Adriazola Semino Miguel, Tejeda Bañez Enrique, Alonso Villalba Antonio, García Cobo Emilio, Romero Rodríguez Francisco, Monfá Bosch José Maria
Servicio de Urología, Hospital Río Carrión, Palencia, España.
Arch Esp Urol. 2002 Jan-Feb;55(1):35-40.
To analyze the probabilities of total PSA, digital rectal examination (DRE) and PSA density in prostate cancer diagnosed by ultrasound-guided sextant prostate biopsy.
The clinical records of 170 patients with elevated PSA levels and/or symptomatic BPH that had been referred to the outpatient services of the urology department were reviewed. Ultrasound-guided sextant prostate biopsy was performed in all patients. Serum PSA and PSA density were determined before biopsy. Age and DRE findings were also analyzed.
RESULTS/CONCLUSIONS: Statistical analysis showed a significant difference (p < 0.00001) for DRE, PSA and PSA density in relation to the prostate biopsy. Concerning the magnitude of the effect of DRE adjusted for age. PSA and PSA density determined by logistic regression analysis, a significance was found for DRE (odds ratio: 9.7) and PSA density > 0.5 (odds ratio: 11.3). DRE showed a sensitivity of 59%, a specificity of 89% and a positive predictive value of 88%.
分析经超声引导的前列腺六分区活检诊断前列腺癌时总前列腺特异性抗原（PSA）、直肠指检（DRE）及PSA密度的诊断概率。
回顾性分析170例因PSA水平升高和/或有症状的良性前列腺增生（BPH）而转诊至泌尿外科门诊的患者的临床记录。所有患者均接受经超声引导的前列腺六分区活检。在活检前测定血清PSA和PSA密度。同时分析患者年龄及直肠指检结果。
结果/结论：统计分析显示，直肠指检、PSA及PSA密度在前列腺活检方面存在显著差异（p < 0.00001）。关于经年龄、PSA及PSA密度校正后的直肠指检的效应大小，经逻辑回归分析发现，直肠指检（比值比：9.7）及PSA密度> 0.5（比值比：11.3）具有统计学意义。直肠指检的敏感性为59%，特异性为89%，阳性预测值为88%。
