Rodríguez Rodríguez R, Mayayo Dehesa T, Galbis Sanjuan F, Jiménez Cidre M, Burgos Revilla F J, Allona Almagro A, Gomez dos Santos V
Unidad de Ecografia Urológica Dr. T. Mayayo, Madrid, España.
Arch Esp Urol. 1997 May;50(4):333-8.
To study the utility of PSA density and predicted PSA results in the diagnosis of prostatic cancer using gland volume.
500 patients suspected as having prostatic cancer underwent ultrasound-guided transrectal biopsy. Prostate volume and ultrasound characteristics, serum PSA density, predicted PSA and the difference between both were determined.
44.8% of the patients showed evidence of cancer in the biopsy specimen. These patients had a significantly smaller prostate. The 0.1 and 0.15 PSA density cutoffs had a sensitivity of 96% and 94%, specificity of 10% and 20% and positive predictive value of 46% and 49%, respectively. The statistical values for PSA difference of 1 and 2 were 94% and 92%, 13% and 18%, 47% and 48%, respectively.
PSA density and predicted PSA results could be useful to avoid biopsies in patients with PSA between 4 and 10 ng/ml and no malignant tumor of the prostate.
利用腺体体积研究前列腺特异抗原（PSA）密度及预测的PSA结果在前列腺癌诊断中的效用。
500例疑似前列腺癌患者接受超声引导下经直肠活检。测定前列腺体积及超声特征、血清PSA密度、预测的PSA以及两者之间的差异。
44.8%的患者活检标本显示有癌症迹象。这些患者的前列腺明显较小。PSA密度临界值为0.1和0.15时，敏感性分别为96%和94%，特异性分别为10%和20%，阳性预测值分别为46%和49%。PSA差异为1和2时的统计值分别为94%和92%、13%和18%、47%和48%。
PSA密度及预测的PSA结果可能有助于避免对PSA在4至10 ng/ml且无前列腺恶性肿瘤的患者进行活检。
