阿霉素在人、猴和大鼠体内的代谢及排泄比较
Comparative metabolism and excretion of adriamycin in man, monkey, and rat.
作者信息
Wilkinson P M, Israel M, Pegg W J, Frei E
出版信息
Cancer Chemother Pharmacol. 1979;2(2):121-5. doi: 10.1007/BF00254084.
PMID:119583
Abstract
Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and highly reproducible high-performance liquid chromatographic procedure. Species differences in metabolism and biliary excretion were observed with respect to aldoketo reductase and conjugase activities.
摘要
采用一种简单、快速且高度可重复的高效液相色谱法测定了阿霉素及其在胆汁（人、猴和大鼠）和尿液（人及猴）中的荧光代谢产物。观察到在醛酮还原酶和结合酶活性方面存在代谢和胆汁排泄的种属差异。
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