阿霉素在正常大鼠和白血病大鼠体内的分布差异。
Different distribution of adriamycin in normal and leukaemic rats.
作者信息
Sonneveld P, Van Bekkum D W
出版信息
Br J Cancer. 1981 Apr;43(4):464-70. doi: 10.1038/bjc.1981.68.
Adriamycin (ADR) accumulates in well-perfused organs in the rat. This effect is especially evident for long periods in marrow and spleen of healthy animals. In rats bearing the Brown Norway Acute Myeloid Leukaemia (BNML) the in vivo distribution is significantly different. Maximum ADR levels in those organs which are morphologically infiltrated by leukaemic cells are significantly lower than in normal rats, while the persistence of measurable ADR concentrations does not change. On the contrary, ADR concentrations in organs not infiltrated by leukaemic cells are the same or slightly higher than in normal rats. Possible causes for these differences are either the differential properties of normal and leukaemic cells in their uptake and excretion of ADR, or anatomical and vascular changes. It is evident that, significantly different from normal. This observation may help in the prevention of toxicity by drug monitoring in serum.
阿霉素（ADR）在大鼠灌注良好的器官中蓄积。这种效应在健康动物的骨髓和脾脏中长时间尤为明显。在患有布朗挪威急性髓性白血病（BNML）的大鼠中，体内分布有显著差异。在那些被白血病细胞形态学浸润的器官中，ADR的最高水平显著低于正常大鼠，而可测量的ADR浓度的持续时间没有变化。相反，未被白血病细胞浸润的器官中的ADR浓度与正常大鼠相同或略高。这些差异的可能原因要么是正常细胞和白血病细胞在摄取和排泄ADR方面的不同特性，要么是解剖学和血管的变化。很明显，与正常情况有显著差异。这一观察结果可能有助于通过监测血清中的药物来预防毒性。
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