Schwentker Ann, Billiar Timothy R
Department of Surgery, University of Pittsburgh Medical Center, 6B Scaife Hall, Terrace Street, Pittsburgh, Pennsylvania 15213, USA.
World J Surg. 2002 Jul;26(7):772-8. doi: 10.1007/s00268-002-4051-7. Epub 2002 Apr 18.
Elucidation of the many roles of nitric oxide (NO) in homeostasis and disease states has uncovered many areas where manipulation of NO production would be of therapeutic benefit. Recent advances in gene transfer technology and the cloning of the inducible nitric oxide synthase (iNOS) gene have led to the development of strategies for gene therapy to increase NO production for the treatment of disorders ranging from vascular restenosis to impaired wound healing. This review summarizes the current status of iNOS gene therapy research.
对一氧化氮（NO）在体内平衡和疾病状态中多种作用的阐明，揭示了许多通过调控NO生成可带来治疗益处的领域。基因转移技术的最新进展以及诱导型一氧化氮合酶（iNOS）基因的克隆，促使了基因治疗策略的发展，以增加NO生成，用于治疗从血管再狭窄到伤口愈合受损等一系列病症。本综述总结了iNOS基因治疗研究的现状。
