Yancy Clyde W
Department of Internal Medicine/Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Curr Cardiol Rep. 2002 May;4(3):218-25. doi: 10.1007/s11886-002-0054-0.
Heart failure in blacks is a unique malady characterized by a different natural history, more worrisome prognosis, and potential variances in the response to current medical therapy for heart failure. The overwhelming burden of hypertension as a putative cause of left ventricular dysfunction identifies this illness. Although differences in the response to medical therapy have been described, angiotensin-converting enzyme inhibitors and beta-blockers remain the most appropriate therapy. Certain genetic polymorphisms may exist that explain the observed differences.
黑人心力衰竭是一种独特的病症，其特点是自然病程不同、预后更令人担忧，以及对目前心力衰竭药物治疗的反应可能存在差异。作为左心室功能障碍的假定病因，高血压的巨大负担凸显了这种疾病。尽管已经描述了药物治疗反应的差异，但血管紧张素转换酶抑制剂和β受体阻滞剂仍然是最合适的治疗方法。可能存在某些基因多态性可以解释观察到的差异。
