3-O-substituted benzyl pyridazinone derivatives as COX inhibitors.

作者信息

Chintakunta Vamsee Krishna, Akella Venkateswarlu, Vedula Manohar Sharma, Mamnoor Prem Kumar, Mishra Parimal, Casturi Seshagiri Rao, Vangoori Akhila, Rajagopalan Ramanujam

机构信息

Discovery Chemistry, Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500050, India.

出版信息

Eur J Med Chem. 2002 Apr;37(4):339-47. doi: 10.1016/s0223-5234(02)01336-3.

New 3-O-substituted benzyl pyridazinone compounds have been synthesised and evaluated for their cyclooxygenase inhibitory activity and COX-2 selectivity. Among the compounds synthesised, three compounds (11b-11d) have shown in vitro COX-2 selectivity. These compounds have been evaluated for their in vivo potential using carrageenan-induced rat paw edema assay. One compound (11b) showed 32% anti-inflammatory activity at 30 mgkg(-1) dose.