Makó S, Stampf G
Igazság Gyógyszertár, Budapest.
Acta Pharm Hung. 2001 Oct;71(3):293-9.
Transdermal therapeutic systems (TTS) gain continuously increasing importance in therapy due to their advantageous properties. They assure constant concentration of the active substance in the blood, a lower amount of the drug compared to the orally administered dose is sufficient, side effects decrease, and the therapy is painless. Since the appearance of the first products many TTSs have been developed containing a wide variety of active substances including hormonal, antihypertensive, antianginal, and analgesic plasters. Nowadays TTSs belong to the most advanced formulations. There is ongoing research in the field of regulating the active substance release with electric current or ultrasound. There are systems containing insulin, cytostatics, antiparkinsonians, contraceptives, and anxiolytics under development.
透皮治疗系统（TTS）因其有利特性在治疗中日益重要。它们可确保血液中活性物质浓度恒定，与口服剂量相比，所需药物量更少，副作用减少，且治疗无痛。自首批产品问世以来，已研发出许多含多种活性物质的TTS，包括激素类、抗高血压类、抗心绞痛类和止痛类贴剂。如今，TTS属于最先进的制剂。目前正在进行利用电流或超声波调节活性物质释放的研究。正在开发含胰岛素、细胞抑制剂、抗帕金森病药物、避孕药和抗焦虑药的系统。
