Grob K
Official Food Control Authority of the Canton of Zurich, Switzerland.
Food Addit Contam. 2002;19 Suppl:185-91. doi: 10.1080/02652030110072713.
The premise is put forward that present European regulation of food-packaging materials does not provide the assessment for safety corresponding to the opinion of toxicologists that migrants ingested in amounts exceeding a threshold of 1.5 microg day(-1) should be identified and toxicologically evaluated. Many substances that migrate (the large majority of the components migrating from can coatings) are neither starting point materials, nor obvious derivatives therefrom, and are, therefore, not covered by existing systems based on positive lists. Safety presupposes the comprehensive analysis of the migrating substances, ultimately to the limits in terms of concentration and molecular weight considered to he of toxicological concern. This is a new analytical challenge. In this paper, expected problems are discussed, leading to the conclusion that it will be difficult to achieve comprehensive analysis down to the concentrations presently considered safe, but that systematic work should start to define the possibilities and limitations of analytical chemistry for a migrate-oriented coating legislation.
本文提出的前提是，目前欧洲对食品包装材料的监管并未按照毒理学家的观点进行安全评估，即对于摄入量超过1.5微克/天阈值的迁移物，应予以识别并进行毒理学评估。许多迁移的物质（从罐头涂层迁移的绝大多数成分）既不是起始原料，也不是其明显的衍生物，因此，基于肯定列表的现有体系并未涵盖这些物质。安全性要求对迁移物质进行全面分析，最终要分析到毒理学关注的浓度和分子量极限。这是一项新的分析挑战。本文讨论了预期问题，得出的结论是，要实现目前认为安全浓度下的全面分析将很困难，但应开展系统性工作，以确定面向迁移物的涂层法规中分析化学的可能性和局限性。
