Hou Chuen-Ru, Chung Kao-Chi, Chen Jo-Tong, Hong Chang-Zern
Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Am J Phys Med Rehabil. 2002 May;81(5):342-9. doi: 10.1097/00002060-200205000-00004.
This study investigated the effect of a calcium channel blocking agent, verapamil, on the spontaneous electrical activity (SEA) in a myofascial trigger spot of biceps femoris muscles of rabbits.
Left and right legs of eight adult New Zealand rabbits were randomly assigned into either experimental or control groups to assess the effect of verapamil on SEA. Verapamil and normal saline were injected into the external iliac artery for experimental and control groups, respectively. The experiment was divided into two phases: Phase A investigated the immediate effect of verapamil on SEA of one active locus, and phase B studied the effect of verapamil on SEA of 25 different active loci. The average integrated value of SEA was used to statistically analyze the effect of verapamil on myofascial trigger-spot sensitivity.
In phase A, conducted on one active locus, the regression analysis results showed that the average integrated value in the verapamil group linearly decreased with time, but the average integrated value did not significantly change with time in the control group. In phase B, which analyzed 25 different active loci, the results indicated that the mean average integrated values in the verapamil group was significantly lower than that of the control group.
Calcium channel blockers can effectively inhibit the SEA of myofascial trigger spots.
本研究调查了钙通道阻滞剂维拉帕米对兔股二头肌肌筋膜触发点自发电活动（SEA）的影响。
将8只成年新西兰兔的左右腿随机分为实验组和对照组，以评估维拉帕米对SEA的影响。分别向实验组和对照组的髂外动脉注射维拉帕米和生理盐水。实验分为两个阶段：A阶段研究维拉帕米对一个活跃位点SEA的即时影响，B阶段研究维拉帕米对25个不同活跃位点SEA的影响。使用SEA的平均积分值对维拉帕米对肌筋膜触发点敏感性的影响进行统计学分析。
在针对一个活跃位点进行的A阶段，回归分析结果显示，维拉帕米组的平均积分值随时间呈线性下降，但对照组的平均积分值随时间无显著变化。在分析25个不同活跃位点的B阶段，结果表明，维拉帕米组的平均积分值显著低于对照组。
钙通道阻滞剂可有效抑制肌筋膜触发点的SEA。
