Chen J T, Chen S M, Kuan T S, Chung K C, Hong C Z
Department of Physical Medicine and Rehabilitation, National Cheng-Kung University Hospital, Tainan, Taiwan.
Arch Phys Med Rehabil. 1998 Jul;79(7):790-4. doi: 10.1016/s0003-9993(98)90357-4.
To investigate the effect of phentolamine, a sympathetic blocking agent, on the spontaneous electrical activity (SEA) recorded from a locus of a myofascial trigger spot (MTrS), equivalent to a human trigger point, in rabbit skeletal muscle.
Randomized control trial.
A university medical laboratory.
Nine adult New Zealand rabbits.
In the experimental group phentolamine mesylate (1mg/kg) was injected into the external iliac artery, followed by flushing with normal saline. The control group was treated with normal saline instead of phentolamine using the same procedure.
SEA was recorded from multiple active loci of MTrSs in the biceps femoris muscle: initially SEA in the same locus was recorded before and immediately after phentolamine (or normal saline) injection; then SEA was recorded from 25 different active loci. The mean of the average integrated signal (AIS) of SEA was analyzed, comparing the effects of phentolamine and normal saline on SEA.
In the same active locus, the AIS of SEA showed statistically a linear decay with time after phentolamine injection, with a correlation coefficient of .56 at p < .05. However, no statistical relationship could be derived for the control group data with time by using regression analysis, probably because of large variations among the rabbits and movement artifacts during the experiment. In 25 different loci in the phentolamine group, the mean of the AIS of SEA (7.92 microV) was significantly lower than that of the control group (9.89 microV) at p < .05.
The results support the hypothesis that the autonomic nervous system is involved in the pathogenesis of myofascial trigger points. The application of the AIS as an evaluation index seems to be feasible in the quantitative measurement of SEA.
研究交感神经阻滞剂酚妥拉明对兔骨骼肌中与人类触发点相当的肌筋膜触发点（MTrS）部位记录的自发电活动（SEA）的影响。
随机对照试验。
大学医学实验室。
9只成年新西兰兔。
实验组将甲磺酸酚妥拉明（1mg/kg）注入髂外动脉，随后用生理盐水冲洗。对照组采用相同程序，用生理盐水代替酚妥拉明进行治疗。
记录股二头肌中多个MTrS活跃部位的SEA：最初在酚妥拉明（或生理盐水）注射前及注射后立即记录同一部位的SEA；然后从25个不同的活跃部位记录SEA。分析SEA平均积分信号（AIS）的均值，比较酚妥拉明和生理盐水对SEA的影响。
在同一活跃部位，酚妥拉明注射后SEA的AIS随时间呈统计学上的线性衰减，p<0.05时相关系数为0.56。然而，对照组数据通过回归分析无法得出与时间的统计关系，可能是由于兔之间差异较大以及实验过程中的运动伪迹。在酚妥拉明组的25个不同部位，SEA的AIS均值（7.92微伏）显著低于对照组（9.89微伏），p<0.05。
结果支持自主神经系统参与肌筋膜触发点发病机制的假说。将AIS作为评估指标应用于SEA的定量测量似乎是可行的。
