Storek Jan, Joseph Ansamma, Dawson Monja A, Douek Daniel C, Storer Barry, Maloney David G
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Transplantation. 2002 Apr 15;73(7):1154-8. doi: 10.1097/00007890-200204150-00026.
In adult recipients of allogeneic hematopoietic cell transplants (HCT) studied at 1 year after grafting, there was a significant correlation between the counts of T cell receptor excision circle (TREC)-containing CD4 T cells (presumed recent thymic emigrants) and the counts of total T cells (r=0.65, P<0.001). Thus, the reconstitution of CD4 T cell pool depends on T cell generation from hematopoietic stem cells (T-lymphopoiesis). We evaluated factors that could affect T-lymphopoiesis. Low TREC-containing CD4 T cell counts were associated with older patient age (r=-0.41, P=0.01) but not with donor age, graft type (marrow vs. blood stem cells), CD34 cell dose, conditioning (with vs. without irradiation), acute graft-versus-host disease (aGVHD), or chronic graft-versus-host disease (cGVHD) in multivariate analysis. We conclude that patient age is the primary determinant of CD4 T-lymphopoiesis after allogeneic HCT.
在移植后1年进行研究的异基因造血细胞移植（HCT）成年受者中，含有T细胞受体切除环（TREC）的CD4 T细胞（推测为近期胸腺迁出细胞）计数与总T细胞计数之间存在显著相关性（r = 0.65，P < 0.001）。因此，CD4 T细胞库的重建依赖于造血干细胞产生T细胞（T淋巴细胞生成）。我们评估了可能影响T淋巴细胞生成的因素。在多变量分析中，含有TREC的CD4 T细胞计数低与患者年龄较大相关（r = -0.41，P = 0.01），但与供者年龄、移植物类型（骨髓与造血干细胞）、CD34细胞剂量、预处理（有或无照射）、急性移植物抗宿主病（aGVHD）或慢性移植物抗宿主病（cGVHD）无关。我们得出结论，患者年龄是异基因HCT后CD4 T淋巴细胞生成的主要决定因素。
