Menda Yusuf, Kahn Daniel
Division of Nuclear Medicine, University of Iowa College of Medicine, Iowa City, IA 52246, USA.
Semin Nucl Med. 2002 Apr;32(2):92-6. doi: 10.1053/snuc.2002.31564.
Several tumors overexpress somatostatin receptors (SSTR) and can thus be imaged with radiolabeled analogues of somatostatin. Tc-99m depreotide is a new radiolabeled somatostatin analogue that shows high affinity for SSTR2, SSTR3, and SSTR5 subtypes. It has been recently FDA-approved for use in the evaluation of indeterminate solitary pulmonary nodules. SPECT with Tc-99m depreotide is highly accurate in this clinical setting and may be preferable to FDG-PET because of its lower cost and wider availability. Large studies are also underway to evaluate the accuracy of Tc-99m depreotide in staging of lung cancer.
几种肿瘤过度表达生长抑素受体（SSTR），因此可用放射性标记的生长抑素类似物进行成像。锝-99m 德普列肽是一种新型放射性标记的生长抑素类似物，对 SSTR2、SSTR3 和 SSTR5 亚型具有高亲和力。它最近已获得美国食品药品监督管理局（FDA）批准，用于评估不确定的孤立性肺结节。在这种临床情况下，锝-99m 德普列肽单光子发射计算机断层扫描（SPECT）具有很高的准确性，并且由于其成本较低且可用性更广，可能比氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）更具优势。目前也正在进行大型研究，以评估锝-99m 德普列肽在肺癌分期中的准确性。
