99mTc 地普奥肽对非小细胞肺癌的生长抑素受体显像
Somatostatin receptor imaging of non-small cell lung cancer with 99mTc depreotide.
作者信息
Menda Yusuf, Kahn Daniel
机构信息
Division of Nuclear Medicine, University of Iowa College of Medicine, Iowa City, IA 52246, USA.
出版信息
Semin Nucl Med. 2002 Apr;32(2):92-6. doi: 10.1053/snuc.2002.31564.
Several tumors overexpress somatostatin receptors (SSTR) and can thus be imaged with radiolabeled analogues of somatostatin. Tc-99m depreotide is a new radiolabeled somatostatin analogue that shows high affinity for SSTR2, SSTR3, and SSTR5 subtypes. It has been recently FDA-approved for use in the evaluation of indeterminate solitary pulmonary nodules. SPECT with Tc-99m depreotide is highly accurate in this clinical setting and may be preferable to FDG-PET because of its lower cost and wider availability. Large studies are also underway to evaluate the accuracy of Tc-99m depreotide in staging of lung cancer.
几种肿瘤过度表达生长抑素受体（SSTR），因此可用放射性标记的生长抑素类似物进行成像。锝-99m 德普列肽是一种新型放射性标记的生长抑素类似物，对 SSTR2、SSTR3 和 SSTR5 亚型具有高亲和力。它最近已获得美国食品药品监督管理局（FDA）批准，用于评估不确定的孤立性肺结节。在这种临床情况下，锝-99m 德普列肽单光子发射计算机断层扫描（SPECT）具有很高的准确性，并且由于其成本较低且可用性更广，可能比氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）更具优势。目前也正在进行大型研究，以评估锝-99m 德普列肽在肺癌分期中的准确性。
Zotero 插件