Kirchner Jeffrey T
Comprehensive Care Clinic for HIV, Department of Family and Community Medicine, Lancaster General Hospital, Lancaster, Pa., USA.
AIDS Read. 2002 Mar;12(3):103-5, 110-2.
Renal failure is a known complication of HIV infection. The most common form is HIV-associated nephropathy, or HIVAN. It is characterized by high-grade proteinuria with rapid progression to end-stage renal disease. The kidneys of affected patients appear enlarged on ultrasonography. Histopathologically, there is focal segmental glomerulosclerosis with glomerular collapse. Before the era of HAART, patients with HIVAN had limited survival, although in some cases this was prolonged if dialysis was instituted. Over the past few years, isolated case reports have shown that patients with HIVAN will recover renal function following initiation of HAART. We report 3 patients believed to have HIVAN who exhibited marked improvement in renal function after treatment with a regimen comprising 2 nucleoside reverse transcriptase inhibitors and a protease inhibitor.
肾衰竭是已知的HIV感染并发症。最常见的形式是HIV相关性肾病（HIVAN）。其特征为大量蛋白尿并迅速进展至终末期肾病。超声检查显示，受影响患者的肾脏肿大。组织病理学上，表现为局灶节段性肾小球硬化伴肾小球塌陷。在高效抗逆转录病毒治疗（HAART）时代之前，HIVAN患者的生存期有限，不过在某些情况下，如果进行透析，生存期会延长。在过去几年中，个别病例报告显示，开始HAART治疗后，HIVAN患者的肾功能会恢复。我们报告了3例被认为患有HIVAN的患者，他们在接受包含2种核苷类逆转录酶抑制剂和1种蛋白酶抑制剂的治疗方案后，肾功能有显著改善。
