慢性丙型肝炎中的疲劳与心理障碍
Fatigue and psychological disorders in chronic hepatitis C.
作者信息
McDonald Jennifer, Jayasuriya Jayasuriya, Bindley Patricia, Gonsalvez Craig, Gluseska Sonja
机构信息
Department of Gastroenterology, Wollongong Hospital, Australia.
出版信息
J Gastroenterol Hepatol. 2002 Feb;17(2):171-6. doi: 10.1046/j.1440-1746.2002.02669.x.
BACKGROUND AND AIM
Most patients with chronic hepatitis C report that they suffer from fatigue. The aim of this study was to determine if the symptom of fatigue can be a guide to indicate disease activity in chronic hepatitis C, or if it is related to psychological factors.
METHODS
115 chronic hepatitis C patients attending a liver clinic at Wollongong Hospital, Wollongong, Australia, were asked to fill out a questionnaire on the functional impact of their fatigue, and a questionnaire on psychological parameters. These were correlated with a history of intravenous drug use, alcohol history, transaminase levels and liver biopsy findings.
RESULTS
Fatigue weakly correlated with the level of fibrosis on the liver biopsy, but strongly correlated with all the psychological domains of depression, anxiety, somatization, interpersonal sensitivity and hostility.
CONCLUSION
The level of fatigue strongly correlated with all the psychological domains, particularly depression, and not with our measures of disease activity.
背景与目的
大多数慢性丙型肝炎患者称自己感到疲劳。本研究的目的是确定疲劳症状是否可作为慢性丙型肝炎疾病活动的指标，或者它是否与心理因素有关。
方法
澳大利亚卧龙岗医院肝病门诊的115名慢性丙型肝炎患者被要求填写一份关于疲劳对其功能影响的问卷，以及一份关于心理参数的问卷。这些问卷与静脉吸毒史、饮酒史、转氨酶水平和肝活检结果相关联。
结果
疲劳与肝活检的纤维化程度呈弱相关，但与抑郁、焦虑、躯体化、人际敏感和敌对情绪等所有心理领域呈强相关。
结论
疲劳程度与所有心理领域，尤其是抑郁，呈强相关，而与我们所测量的疾病活动度无关。
Zotero 插件