Nishiki S, Hino M, Kumura T, Hashimoto S, Ohta K, Yamane T, Takubo T, Tatsumi N, Kitagawa S, Kamitani T, Watanabe Y, Shimada E, Juji T, Iida S
Department of Clinical Hematology and Diagnostics, Osaka City University, Graduate School of Medicine, Japan.
Transfus Med. 2002 Feb;12(1):71-3. doi: 10.1046/j.1365-3148.2002.00350.x.
A 71-year-old Japanese male with myelodysplastic syndrome progressing to overt leukaemia and hepatocellular carcinoma developed dyspnea and urticaria immediately after infusion of platelet concentrate (PC). He exhibited an identical reaction following blood transfusion. Serum haptoglobin was undetectable. The patient was determined to be homozygous for Hp(del) by polymerase chain reaction (PCR). Antibody to haptoglobin was detected by enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. No antibodies against human leucocyte antigen (HLA) or platelet-specific antigens were detected. Washed PC and washed red blood cells were effective in preventing the transfusion-related anaphylactoid reactions.
一名71岁的日本男性，患有骨髓增生异常综合征并进展为明显白血病和肝细胞癌，在输注血小板浓缩液（PC）后立即出现呼吸困难和荨麻疹。他在输血后出现了相同的反应。血清触珠蛋白检测不到。通过聚合酶链反应（PCR）确定该患者为Hp(del)纯合子。通过酶联免疫吸附测定（ELISA）和蛋白质印迹分析检测到了抗触珠蛋白抗体。未检测到针对人类白细胞抗原（HLA）或血小板特异性抗原的抗体。洗涤后的PC和洗涤后的红细胞可有效预防输血相关类过敏反应。
