Hartwig D, Schläger F, Bucsky P, Kirchner H, Schlenke P
Institute for Immunology and Transfusion Medicine, Medical University of Lübeck, Germany.
Transfus Med. 2002 Feb;12(1):75-7. doi: 10.1046/j.1365-3148.2002.00346.x.
The use of long-term automated erythrocytapheresis via an arterio-venous fistula for the prevention of recurrent ischaemic stroke in a child with sickle-cell disease (SCD) has not been described previously. We report the successful use of this technique in a 13-year-old boy. A procedure was performed every 36 +/- 6 days, transfusing six units of donor packed red blood cells (RBCs) and discarding 1318 +/- 174 mL of exchanged erythrocytes (Hct 60%). After transfusion of 85 units over 17 months, there is no evidence for iron-overload, red cell alloimmunization, transfusion-transmitted infections, or other complications. Until now, no cerebrovascular ischaemia has been observed.
此前尚未有关于通过动静脉瘘进行长期自动红细胞单采术预防镰状细胞病（SCD）患儿复发性缺血性卒中的报道。我们报告了该技术在一名13岁男孩中的成功应用。每36±6天进行一次操作，输注6单位供体浓缩红细胞（RBC），并弃去1318±174 mL置换的红细胞（血细胞比容60%）。在17个月内输注85单位后，没有铁过载、红细胞同种免疫、输血传播感染或其他并发症的证据。到目前为止，未观察到脑血管缺血。
