Kozanoglu Ilknur, Boga Can, Ozdogu Hakan, Sezgin Nurzen, Kizilkilic Ebru, Kural Mahmut
Department of Physiology, Baskent University, Faculty of Medicine, 06490-Ankara, Turkey.
Transfus Apher Sci. 2007 Jun;36(3):305-12. doi: 10.1016/j.transci.2007.03.012. Epub 2007 Jun 20.
In automated red cell exchange, about 60% of the patient's red blood cells are exchanged via apheresis for those of the donor. We report the outcome of 83 patients with sickle cell anemia (48 women and 35 men; age range, 17-49 years) who underwent a total of 196 apheresis procedures between December 2003 and October 2006 at our institution. We found that automated red cell exchange involving a reduced citrate infusion rate may provide benefit in the prevention or treatment of vaso-occlusive complications in patients with sickle cell disease and may be associated with protean effects on biochemical dynamics.
在自动红细胞置换过程中，约60%的患者红细胞通过单采术被供者的红细胞所置换。我们报告了2003年12月至2006年10月在我院接受治疗的83例镰状细胞贫血患者（48例女性和35例男性；年龄范围17 - 49岁）的治疗结果，这些患者共接受了196次单采术。我们发现，降低枸橼酸盐输注速率的自动红细胞置换可能有助于预防或治疗镰状细胞病患者的血管闭塞性并发症，并且可能对生化动力学产生多种影响。
