Pricop Luminita, Salmon Jane E
Hospital for Special Surgery and Weill Medical College of Cornell University, Department of Medicine, New York, NY 10021, USA.
Antioxid Redox Signal. 2002 Feb;4(1):85-95. doi: 10.1089/152308602753625889.
Recent advances in our understanding of the mechanisms that regulate acute and chronic inflammatory responses have revealed a key role for reactive oxygen intermediates in modulating the activation of neutrophils. Opsonized microbes and immune complexes initiate the oxidative burst by the engagement of receptors for immunoglobulin G, termed Fcgamma receptors. The regulation of phagocytic cell function by oxidant-sensitive signaling pathways optimizes host defense capabilities, but it also amplifies tissue damage. This review will focus on the cross-talk between Fcgamma receptors and reactive oxygen intermediates at sites of inflammation and its role in microbial immunity.
我们对调节急性和慢性炎症反应机制的理解取得了新进展，这揭示了活性氧中间体在调节中性粒细胞激活中起关键作用。经调理的微生物和免疫复合物通过免疫球蛋白G受体（称为Fcγ受体）的结合引发氧化爆发。氧化敏感信号通路对吞噬细胞功能的调节优化了宿主防御能力，但也加剧了组织损伤。本综述将聚焦于炎症部位Fcγ受体与活性氧中间体之间的相互作用及其在微生物免疫中的作用。
