Lu Xiaofeng, Matsuzawa Masako, Hikosaka Okihide
Department of Physiology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan.
Neuron. 2002 Apr 11;34(2):317-25. doi: 10.1016/s0896-6273(02)00657-8.
Complex learned motor sequences can be composed of a combination of a small number of elementary actions. To investigate how the brain represents such sequences, we devised an oculomotor sequence task in which the monkey had to choose the target solely by the sequential context, not by the current stimulus combination. We found that many neurons in the supplementary eye field (SEF) became active with a specific target direction (D neuron) or a specific target/distractor combination (C neuron). Furthermore, such activity was often selective for one among several sequences that included the combination (S neuron). These results suggest that the SEF contributes to the generation of saccades in many learned sequences.
复杂的习得性运动序列可由少量基本动作组合而成。为了研究大脑如何表征此类序列，我们设计了一项眼球运动序列任务，在此任务中，猴子必须仅根据序列上下文而非当前刺激组合来选择目标。我们发现，辅助眼区（SEF）中的许多神经元会随着特定目标方向（D神经元）或特定目标/干扰物组合（C神经元）而变得活跃。此外，这种活动通常对包含该组合的几个序列中的一个具有选择性（S神经元）。这些结果表明，辅助眼区在许多习得序列中对扫视的产生有贡献。
