Fackler Oliver T, Baur Andreas S
Department of Virology, University of Heidelberg, D-69120 Heidelberg, Germany.
Immunity. 2002 Apr;16(4):493-7. doi: 10.1016/s1074-7613(02)00307-2.
The viral Nef protein is important for the progression of the human and simian immunodeficiency virus (HIV/SIV) infection. So far, experimental evidence has suggested that Nef enhances viral replication and infectivity through a combination of different effects. Recent insights, however, indicate that its functions are more complex than previously anticipated. By targeting the T cell receptor, Nef may not only prime viral replication but, more importantly, ensure viral survival through distinct mechanisms of immune evasion and antiapoptosis.
病毒Nef蛋白对于人类和猿猴免疫缺陷病毒（HIV/SIV）感染的进展至关重要。到目前为止，实验证据表明，Nef通过多种不同作用的组合来增强病毒复制和感染性。然而，最近的研究见解表明，其功能比先前预期的更为复杂。通过靶向T细胞受体，Nef不仅可能启动病毒复制，更重要的是，通过独特的免疫逃避和抗凋亡机制确保病毒存活。
