Maxwell M H
Postgrad Med. 1975 Nov;Spec No:36-41.
This study was designed to determine the effects on renal function and fluid-electrolyte metabolism of prazosin administered intravenously in a single dose and administered orally in a single dose and in multiple doses to patients with essential hypertension. The results indicate that clinically effective doses of prazosin do not observably alter parameters of kidney function. No side effects were reported by patients, all of whom followed the medication schedule as prescribed (adherence was confirmed by measurement of blood levels of the agent).
本研究旨在确定单剂量静脉注射、单剂量口服以及多剂量口服哌唑嗪对原发性高血压患者肾功能和体液电解质代谢的影响。结果表明，临床有效剂量的哌唑嗪未显著改变肾功能参数。患者均未报告有副作用，所有患者均按规定的用药方案服药（通过测量药物的血药浓度确认依从性）。
