Bjerregaard Lise Lotte, Rosthoøj Steen
Department of Pediatrics, Aalborg Hospital, Aalborg, Denmark.
J Pediatr Hematol Oncol. 2002 May;24(4):313-5. doi: 10.1097/00043426-200205000-00019.
A 10-year-old girl, presenting with fever, eosinophilia, and back pain, was diagnosed with pre-B CD10-positive acute lymphoblastic leukemia. Eosinophilia resolved rapidly during remission induction treatment, but diffuse spinal osteopenia with multiple compression fractures became manifest after 4 weeks. During subsequent treatment the spine remineralized slowly, and after 26 months vertebral bone regeneration was apparent. Eosinophilia and osteopenia are separately known as early manifestations of acute lymphoblastic leukemia, but their simultaneous occurrence is particularly interesting. A late bone marrow relapse was not accompanied by bone changes or eosinophilia.
一名10岁女孩，出现发热、嗜酸性粒细胞增多和背痛症状，被诊断为前B细胞CD10阳性急性淋巴细胞白血病。在诱导缓解治疗期间，嗜酸性粒细胞增多迅速缓解，但4周后出现弥漫性脊柱骨质减少并伴有多处压缩性骨折。在随后的治疗过程中，脊柱缓慢再矿化，26个月后椎体骨再生明显。嗜酸性粒细胞增多和骨质减少分别是急性淋巴细胞白血病的早期表现，但它们同时出现尤其令人关注。晚期骨髓复发并未伴有骨骼变化或嗜酸性粒细胞增多。
