Griffiths Emily K, Penninger Josef M
Amgen, Department of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Ontario M5G 2C1, Toronto, Canada.
Curr Opin Immunol. 2002 Jun;14(3):317-22. doi: 10.1016/s0952-7915(02)00334-5.
TCR stimulation induces integrin-mediated adhesion, facilitating stabilization of conjugates between T cells and antigen-presenting cells and thereby contributing to T cell activation. Integrin activation has been shown to require cytoskeletal reorganization; however, the molecular mechanisms mediating communication between the TCR and integrins remain unclear. Recently the adapter protein ADAP/Fyb/Slap has been shown to couple TCR stimulation to integrin activation by mediating increased integrin avidity. ADAP may also play a role in transduction of external signals by integrins. Like other adapters, ADAP is a multifunctional protein and interacts with molecules such as Fyn, Slp-76, Ena/VASP proteins, Vav1, WASP and the Arp2/3 complex.
TCR刺激诱导整合素介导的黏附，促进T细胞与抗原呈递细胞之间结合物的稳定，从而有助于T细胞活化。整合素激活已被证明需要细胞骨架重组；然而，介导TCR与整合素之间通讯的分子机制仍不清楚。最近，衔接蛋白ADAP/Fyb/Slap已被证明通过介导整合素亲和力增加，将TCR刺激与整合素激活联系起来。ADAP也可能在整合素转导外部信号中发挥作用。与其他衔接蛋白一样，ADAP是一种多功能蛋白，可与Fyn、Slp-76、Ena/VASP蛋白、Vav1、WASP和Arp2/3复合体等分子相互作用。
