Barton Gregory M, Medzhitov Ruslan
Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, BML 458, New Haven, CT 06520, USA.
Curr Opin Immunol. 2002 Jun;14(3):380-3. doi: 10.1016/s0952-7915(02)00343-6.
Recently, there has been considerable interest in how adaptive immune responses are controlled by the innate immune system. In particular, researchers have focused on how the differentiation of CD4 T cells is directed upon priming by dendritic cells. The identification of the Toll-like receptors as a family of pattern-recognition receptors involved in controlling dendritic cell activation has focused attention on these receptors as possible regulators of adaptive immune responses. However, recent studies have suggested that Toll-like receptors may only control the induction of Th1 responses and that a separate system of recognition regulates Th2 responses.
最近，关于固有免疫系统如何控制适应性免疫反应引起了人们极大的兴趣。特别是，研究人员专注于树突状细胞启动时CD4 T细胞的分化是如何被引导的。Toll样受体作为参与控制树突状细胞激活的一类模式识别受体被鉴定出来，这使得人们将注意力集中在这些受体上，认为它们可能是适应性免疫反应的调节因子。然而，最近的研究表明，Toll样受体可能仅控制Th1反应的诱导，而一个独立的识别系统调节Th2反应。
