Lacroix C, Peureux M, Borel M, Goulle J
Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre, France.
Acta Clin Belg. 2002;57 Suppl 1:58-62.
Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1% following repeated Xylocaine gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.
利多卡因的使用可能导致高铁血红蛋白血症。利多卡因在临床上广泛用作麻醉药物，但其毒性作用较为罕见。我们报告了在多次口服赛罗卡因凝胶后高铁血红蛋白血症水平高达31.1%的情况。已有报道称利多卡因在人体内有导致生成二甲基苯基羟胺的新代谢途径。这种代谢与苯胺衍生物的代谢非常相似，可能解释了利多卡因导致高铁血红蛋白血症的作用。
